T-lymphocyte dysfunctions occurring together with apical gut epithelial cell autoantibodies
- PMID: 2065915
- DOI: 10.1016/0016-5085(91)90016-e
T-lymphocyte dysfunctions occurring together with apical gut epithelial cell autoantibodies
Abstract
Gut epithelial cell autoantibodies have been considered a hallmark of autoimmune enteropathy, a disorder occurring in children with protracted diarrhea of unknown etiology. Four patients (two male and two female) with such autoantibodies were studied. Immunofluorescence analysis showed two different disjunctive staining patterns: complement-fixing apical (three of four) and cytoplasmic (the remaining fourth one), which are shown to be directed against different structures. All three patients positive for complement-fixing apical gut epithelial cell autoantibodies had abnormal T-cell responses in vitro, one of them with an immunoglobulin G2 immunoglobulin deficiency and another with an immunoglobulin A deficiency. An immunoglobulin A deficiency without T-cell alterations was also diagnosed in the cytoplasmic gut epithelial cell autoantibody-positive patient. These findings suggest that different immunologic alterations (either a T-cell abnormality or immunoglobulin deficiency) may favor the appearance of gut epithelial cell autoantibodies (complement-fixing apical or cytoplasmic, respectively). Furthermore, these autoantibodies should not be considered a specific marker of autoimmune enteropathy, because they may not always be associated with such a disease: two patients with apical gut epithelial cell autoantibodies showed no signs of intestinal lesion or diarrhea.
Similar articles
-
Specific autoantibodies to gut epithelium in two infants with severe protracted diarrhoea.J Pediatr Gastroenterol Nutr. 1985 Apr;4(2):187-95. doi: 10.1097/00005176-198504000-00006. J Pediatr Gastroenterol Nutr. 1985. PMID: 3886868
-
Autoimmune enteropathy and colitis: is there a generalised autoimmune gut disorder?Gut. 1991 Jan;32(1):36-42. doi: 10.1136/gut.32.1.36. Gut. 1991. PMID: 1991636 Free PMC article.
-
Autoantibodies in patients with IgA and IgG2 deficiencies.APMIS. 1991 Apr;99(4):327-32. doi: 10.1111/j.1699-0463.1991.tb05157.x. APMIS. 1991. PMID: 2036215
-
Intestinal goblet cell autoantibody associated enteropathy.J Clin Pathol. 2003 Aug;56(8):629-30. doi: 10.1136/jcp.56.8.629. J Clin Pathol. 2003. PMID: 12890820 Free PMC article. Review.
-
[IgG subclass deficiencies].Arch Fr Pediatr. 1990 Mar;47(3):213-9. Arch Fr Pediatr. 1990. PMID: 2188632 Review. French. No abstract available.
Cited by
-
An approach to duodenal biopsies.J Clin Pathol. 2006 Nov;59(11):1133-50. doi: 10.1136/jcp.2005.031260. Epub 2006 May 5. J Clin Pathol. 2006. PMID: 16679353 Free PMC article. Review.
-
Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease.Clin Exp Immunol. 2002 Apr;128(1):88-93. doi: 10.1046/j.1365-2249.2002.01795.x. Clin Exp Immunol. 2002. PMID: 11982595 Free PMC article.
-
Autoimmune enteropathy and colitis in an adult patient.Dig Dis Sci. 2003 Aug;48(8):1600-6. doi: 10.1023/a:1024705032326. Dig Dis Sci. 2003. PMID: 12924654
-
Consideration of Maternal Anti-enterocyte IgA Transfer With Resulting Infantile Alloimmune Enteropathy.ACG Case Rep J. 2019 Jun 14;6(6):e00093. doi: 10.14309/crj.0000000000000093. eCollection 2019 Jun. ACG Case Rep J. 2019. PMID: 31616766 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources