Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov;49(11):2117-21.
doi: 10.1093/rheumatology/keq225. Epub 2010 Jul 25.

Salivary gland biopsy: a comprehensive review of techniques and related complications

Giuseppe Colella  1 , Rosangela Cannavale, Antonio Vicidomini, Angelo Itro
Affiliations

Salivary gland biopsy: a comprehensive review of techniques and related complications

Giuseppe Colella et al. Rheumatology (Oxford). 2010 Nov.

Abstract

Objective: This study proposes a revision of the literature on the current techniques employed in salivary gland biopsy.

Methods: A systematic review of the literature between January 1990 and January 2010 was conducted using MEDLINE, Embase and the Cochrane Central Register of Controlled Trials. The search terms were: 'biopsy AND parotid AND Sjögren'; 'biopsy AND sublingual salivary gland AND Sjögren'; 'biopsy AND minor salivary gland AND Sjögren'; 'biopsy AND labial salivary gland AND Sjögren' and 'biopsy AND salivary glands AND connective disorders'.

Results: No study reporting submandibular salivary gland biopsy was found; 3 studies reported sublingual salivary gland biopsy; 1 study reported palate biopsy; 4 studies reported parotid gland biopsy and 21 studies reported minor salivary gland biopsy.

Conclusion: Biopsy of salivary glands must be performed as last investigation and only when the other items are not complete enough to satisfy the diagnosis. The knowledge of complications and sequelae may be useful in order to minimize the risk.

PubMed Disclaimer

Publication types