Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Aug 3;107(31):13563-4.
doi: 10.1073/pnas.1008672107. Epub 2010 Jul 26.

Stalking influenza

Debra M Eckert  1 , Michael S Kay
Affiliations
Comment

Stalking influenza

Debra M Eckert et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Structures defining the conformational changes of HA-induced membrane fusion. (A) The primary structure of cleaved HA. Color indicates the regions defined in B. (B) Two high-resolution structures of influenza HA representing the prefusion neutral-pH (Left) (16) and postfusion low-pH conformations (Right) (17). Trimers are depicted with HA1 (yellow) and HA2 (gray). One monomer is colored to indicate residues present in the HA2-stalk antigen, HA6 (2) (HA1 7–46 and 290–321 are red; HA2 1–172 is blue). Two regions within HA2 (and HA6) that change conformation between the neutral-pH and low-pH structures are indicated (55–76 in cyan and 106–112 in orange). Figure drawn with PyMOL.
See this image and copyright information in PMC

Comment on

References

    1. Skehel JJ, Wiley DC. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem. 2000;69:531–569. - PubMed
    1. Bommakanti G, et al. Design of an HA2 based E. coli expressed influenza immunogen that protects mice from lethal challenge. Proc Natl Acad Sci USA. 2010;107:13701–13706. - PMC - PubMed
    1. Knossow M, Skehel JJ. Variation and infectivity neutralization in influenza. Immunology. 2006;119:1–7. - PMC - PubMed
    1. Wiley DC, Wilson IA, Skehel JJ. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature. 1981;289:373–378. - PubMed
    1. Okuno Y, Isegawa Y, Sasao F, Ueda S. A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. J Virol. 1993;67:2552–2558. - PMC - PubMed

Publication types

MeSH terms

Substances