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Review
. 2011 Jul;79(1):1-16.
doi: 10.1016/j.critrevonc.2010.05.011. Epub 2010 Jul 21.

MUTYH-associated polyposis (MAP)

Maartje Nielsen  1 , Hans Morreau, Hans F A Vasen, Frederik J Hes
Affiliations
Review

MUTYH-associated polyposis (MAP)

Maartje Nielsen et al. Crit Rev Oncol Hematol. 2011 Jul.

Abstract

The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined. Finally, the role of other base excision repair genes in polyposis and CRC patients is discussed.

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