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Review
. 2010 Dec;15(6):313-8.
doi: 10.1016/j.siny.2010.06.002.

Genetics and developmental pathology of twinning

Martin A Weber  1 , Neil J Sebire
Affiliations
Review

Genetics and developmental pathology of twinning

Martin A Weber et al. Semin Fetal Neonatal Med. 2010 Dec.

Abstract

Twin pregnancy is associated with a high risk of congenital malformations. This review covers the risk of such anomalies in both dizygotic and monozygotic twin pregnancies, and discusses current insights into the associations relating to zygosity, chorionicity and genetic factors. The pathological basis of specific malformations unique to the monochorionic twinning process, including conjoined twinning and twin reversed arterial perfusion (TRAP) sequence, is discussed in more detail, and factors contributing to the higher perinatal mortality rate in multiple pregnancies are addressed.

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