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. 1978 Apr 1;147(4):1126-41.
doi: 10.1084/jem.147.4.1126.

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells

N Rosenberg, D Baltimore

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells

N Rosenberg et al. J Exp Med. .

Abstract

Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.

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