Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul;47(1):32-6.
doi: 10.3164/jcbn.10-07. Epub 2010 Apr 23.

Energy expenditure in Japanese patients with severe or moderate ulcerative colitis

Masaya Sasaki  1 , Tomoko Johtatsu, Mika Kurihara, Hiromi Iwakawa, Toshihiro Tanaka, Shigeki Bamba, Tomoyuki Tsujikawa, Yoshihide Fujiyama, Akira Andoh
Affiliations

Energy expenditure in Japanese patients with severe or moderate ulcerative colitis

Masaya Sasaki et al. J Clin Biochem Nutr. 2010 Jul.

Abstract

We investigated the energy expenditure in hospitalized patients with severe or moderate ulcerative colitis (UC), and compared them to healthy controls. Thirteen patients (5 women and 8 men; mean age 31.8 years; mean BMI 19.0 kg/m(2)) and 10 healthy volunteers were enrolled in this study. The resting energy expenditure (mREE) levels were determined by indirect calorimetry. The mREEs of the UC patients were significantly higher than those of healthy controls (26.4 +/- 3.6 vs 21.8 +/- 1.7 kcal/kg/day), although the mREEs of the UC patients were almost the same as the predicted REEs (pREEs) calculated by the Harris-Benedict equation (26.4 +/- 2.4 kcal/kg/day vs 26.5 +/- 2.6 kcal/kg/day). The mREE/pREE ratio, which reflects stress, was 1.0 +/- 0.15. In the UC patients, a significant correlation was observed between the mREEs and the clinical activity index. In conclusion, UC patients showed a hyper-metabolic status as evaluated by their mREE/body weight. Energy expenditure was significantly correlated with disease activity. From our observations, we recommend that nutritional management with more than 30-35 kcal/ideal body weight/day (calculated by the mREE x activity factor) may be optimal for active severe or moderate ulcerative colitis.

Keywords: indirect calorimetry; resting energy expenditure; ulcerative colitis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Correlation between the measured resting energy expenditure (mREE) and the predicted resting energy expenditure (pREE). The mREE was measured by indirect calorimetry, and the pREE was calculated by the Harris-Benedict equation. There was a positive correlation between the mREE and pREE in UC patients.
Fig. 2
Fig. 2
Correlation between the mREE and disease activity index in UC patients (n = 13). The mREE in UC patients exhibited a positive correlation with the disease activity index.
See this image and copyright information in PMC

References

    1. Baumgart D.C., Sandborn W.J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007;369:1641–1657. - PubMed
    1. Baumgart D.C., Carding S.R. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369:1627–1640. - PubMed
    1. Han P.D., Burke A., Baldassano R.N., Rombeau J.L., Lichtenstein G.R. Nutrition and inflammatory bowel disease. Gatroenterol. Clin. North Am. 1999;28:423–443. - PubMed
    1. Hrabovský V., Zadák Z., Bláha V., Hyspler R., Karlík T., Martínek A., Mendlová A. Cholesterol metabolism in active Crohn’s disease. Wien. Klin. Wochenschr. 2009;121:270–275. - PubMed
    1. Barot L.R., Rombeau J.L., Steinberg J.J., Crosby L.O., Feurer I.D., Mullen J.L. Energy expenditure in patients with inflammatory bowel disease. Ann. Surg. 1981;116:460–462. - PubMed