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Case Reports
. 2010 Nov;112(9):829-31.
doi: 10.1016/j.clineuro.2010.06.017. Epub 2010 Jul 25.

Hemorrhagic leukoencephalitis linked to Epstein-Barr virus in an adult patient

P Befort  1 , N Gaillard, C Roubille, A Le Quellec
Affiliations
Case Reports

Hemorrhagic leukoencephalitis linked to Epstein-Barr virus in an adult patient

P Befort et al. Clin Neurol Neurosurg. 2010 Nov.

Abstract

We report a case of an adult patient who presented a febrile coma linked to Epstein-Barr virus (EBV) encephalitis. EBV polymerase chain reaction (PCR) was positive in cerebrospinal fluid (CSF) and blood serology and PCR in blood was consistent with an EBV reactivation. First cerebral magnetic resonance imaging (MRI) at day 1 was normal but a second MRI at day 13 showed anomaly compatible with a hemorrhagic leukoencephalitis. Treatment consists of intravenous corticotherapy and aciclovir during 21 days. Evolution was favourable with complete neurologic recuperation and no intercurrent lymphoma or vasculitis in 6 months follow-up.

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