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. 2009 Jan;30(1):20-3.
doi: 10.4103/0971-5851.56331.

Primary pancreatic lymphoma: Report of three cases with review of literature

Altaf Gauhar Haji  1 , Shekhar Sharma, K Abdul Majeed, D K Vijaykumar, K Pavithran, M Dinesh
Affiliations

Primary pancreatic lymphoma: Report of three cases with review of literature

Altaf Gauhar Haji et al. Indian J Med Paediatr Oncol. 2009 Jan.

Abstract

Background: Primary pancreatic lymphoma (PPL) is an extremely rare neoplasm, which may be confused with pancreatic adenocarcinoma. So far only about 150 cases of PPL have been reported.

Materials and methods: We present our experience of 3 cases of PPL over a 4-year period.

Results: All the patients presented with vague abdominal pain of duration ranging from 1(1/2) months to 3 months. Two patients had diagnosis confirmed histologically by CT-guided core biopsy or Fine needle aspiration procedure. We were able to avoid unnecessary laparotomy in 2 patients using preoperative guided Fine needle aspiration Cytology, although the third patient did undergo a Whipple's procedure as the diagnosis of PPL was not considered during the initial workup.

Conclusions: There is no significant difference noted with regard to patient's age or duration of symptoms between patients with either pancreatic adenocarcinoma or PPL. The differential diagnosis of PPL includes pancreatic adenocarcinoma and secondary involvement of pancreas from extra-nodal lymphoma. Combination of two things is suggestive of Pancreatic lymphoma: (1) Bulky localized tumor in pancreatic head (2) Absence of significant dilatation of main pancreatic duct strengthens a diagnosis of pancreatic lymphoma over adenocarcinoma. Majority of patients can be managed with chemotherapy with much better prognosis compared to patients with pancreatic adenocarcinoma. Larger series of patients are needed to evaluate whether chemotherapy, eventually followed by involved-field radiation therapy, is the treatment of choice for PPL.

Keywords: Pancreatic lymphoma; neoplasm; pancreatic adenocarcinoma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
CT scan showing diffuse homogenous enlargement of pancreatic parenchyma (large arrow) with regional nodal disease (small arrow)
Figure 2
Figure 2
Photomicrograph of (a) H and E, ×40 section and (b) immunohistochemistry, ×100 of CD 20 from tumor showing monotonous population of small round cells with scanty cytoplasm, coarse nuclear chromatin and prominent nucleoli in the pancreatic parenchyma
See this image and copyright information in PMC

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