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Comment
. 2010 Jul 29;466(7306):571-2.
doi: 10.1038/466571a.

Metabolism: Tick, tock, a beta-cell clock

Katja A Lamia, Ronald M Evans
Comment

Metabolism: Tick, tock, a beta-cell clock

Katja A Lamia et al. Nature. .

Abstract

The daily light–dark cycle affects many aspects of normal physiology through the activity of circadian clocks. It emerges that the pancreas has a clock of its own, which responds to energy fluctuations.

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Figures

Figure 1
Figure 1. Going by the local clock
In response to the daily light–dark cycle, the clock in the suprachiasmatic nucleus of the brain regulates metabolism by affecting rhythmic behaviour such as feeding. Marcheva et al. show that the pancreas also has a local clock, which directly affects insulin secretion in response to high blood glucose levels.
See this image and copyright information in PMC

Comment on

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