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Review
. 2010:2010:802078.
doi: 10.1155/2010/802078. Epub 2010 Jul 1.

The role of adipose tissue and adipokines in obesity-related inflammatory diseases

Carmela Rita Balistreri  1 , Calogero Caruso, Giuseppina Candore
Affiliations
Review

The role of adipose tissue and adipokines in obesity-related inflammatory diseases

Carmela Rita Balistreri et al. Mediators Inflamm. 2010.

Abstract

Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.

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Figures

Figure 1
Figure 1
A common yet preventable risk factor for these multifactorial age-related diseases is the visceral obesity. Metabolic syndrome is also associated with obesity. It assembles some abnormalities, including insulin resistance, hyperinsulinemia, hypertension, and dysplipidemia, all risk factors directly associated with both type 2 diabetes and cardiovascular diseases.
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