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. 2010:2010:149149.
doi: 10.1155/2010/149149. Epub 2010 Jul 1.

Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]

Shadia A Elsayed  1 , Ahmed M El-Hendawy, Sahar I Mostafa, Bertrand J Jean-Claude, Margarita Todorova, Ian S Butler
Affiliations

Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl]

Shadia A Elsayed et al. Bioinorg Chem Appl. 2010.

Abstract

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).

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Figures

Figure 1
Figure 1
Structure of 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC).
Figure 2
Figure 2
Structure of [VO2(mpETSC)] with numbering scheme.
Figure 3
Figure 3
Hydrogen bonding interaction in the lattice of [VO2(mpETSC)].
Figure 4
Figure 4
Structure of [Pt(mpETSC)Cl] with numbering scheme.
Figure 5
Figure 5
Hydrogen bonding interaction in the lattice of [Pt(mpETSC)Cl].
Figure 6
Figure 6
Antineoplastic activity in human colon carcinoma HCT116 cells by a growth inhibition SRB assay after 96-hour treatment of HmpETSC, [Zn(HmpETSC)Cl2], and [Pd(mpETSC)Cl].
See this image and copyright information in PMC

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