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. 2010 Oct 7;8(19):4255-8.
doi: 10.1039/c003004j. Epub 2010 Jul 29.

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives

Francisco Palacios  1 , Tomasz K Olszewski, Javier Vicario
Affiliations

Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives

Francisco Palacios et al. Org Biomol Chem. .

Abstract

Efficient synthesis of alpha-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.

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