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. 2010 Sep 1;20(17):5170-4.
doi: 10.1016/j.bmcl.2010.07.008. Epub 2010 Jul 8.

Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors

David B Belanger  1 , Patrick J Curran, Alan Hruza, Johannes Voigt, Zhaoyang Meng, Amit K Mandal, M Arshad Siddiqui, Andrea D Basso, Kimberly Gray
Affiliations

Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors

David B Belanger et al. Bioorg Med Chem Lett. .

Abstract

The synthesis and structure-activity relationships (SAR) of novel, potent imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo[1,2-a]pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.

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