Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;12(10):760-8.
doi: 10.1016/j.jfms.2010.04.010. Epub 2010 Jul 31.

Epidermal growth factor receptor expression is predictive of poor prognosis in feline cutaneous squamous cell carcinoma

Silvia Sabattini  1 , Laura Marconato, Aurora Zoff, Maria Morini, Filippo Scarpa, Ombretta Capitani, Giuliano Bettini
Affiliations

Epidermal growth factor receptor expression is predictive of poor prognosis in feline cutaneous squamous cell carcinoma

Silvia Sabattini et al. J Feline Med Surg. 2010 Oct.

Abstract

The aim of this study was to investigate epidermal growth factor receptor (EGFR) expression in feline cutaneous squamous cell carcinoma (FC-SCC) and assess its prognostic role. Nineteen formalin-fixed paraffin-embedded excisional biopsies of FC-SCC were tested for EGFR expression using immunohistochemistry (IHC). Relationships between EGFR expression and histopathological parameters (differentiation, mitotic activity), disease-free interval (DFI) and overall survival (OS) at 24 months were further investigated. Fourteen of 19 tumours (73.7%) were positive for EGFR, with great variation in intensity and proportion of labelled cells. EGFR expression was not correlated with tumour differentiation or mitotic activity. Nine cats (47.4%) died of tumour-related causes. Patients with EGFR-positive tumours had a significantly worse outcome (P=0.0217), with decreased DFIs (P=0.0075) and survival times (P=0.0391). These data suggest that EGFR expression carries a negative prognostic significance in FC-SCC. EGFR inhibitors in association with conventional treatments may improve outcome for the subgroup of cats with EGFR-positive tumours.

PubMed Disclaimer

References

    1. Miller M.A.,Nelson S.L.,Turk J.R., et al.Cutaneous neoplasia in 240 cats.Vet Pathol. 1991;28:389-395 - PubMed
    1. Ogilvie G.K.,Moore A.S.Feline oncology. A comprehensive guide to compassionate care. Trenton: Veterinary Learning Systems; 2001:
    1. Goldschmidt M.H.,Shofer F.S.Skin tumors of the dog and the cat.. 1st ednNew York: Pergamon Press; 1992:37-50.
    1. Favrot C.,Welle M.,Heimann M.,Godson D.L.,Guscetti F..Clinical, histologic and immunohistochemical analyses of feline squamous cell carcinoma in situ.Vet Pathol. 2009;46:25-33 - PubMed
    1. Ongkeko W.M.,Altuna X.,Weisman R.A.,Wang-Rodriguez J..Expression of protein tyrosine kinases in head and neck squamous cell carcinomas.Am J Clin Pathol. 2005;124:71-76 - PubMed