Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 Nov;31(6):589-603.
doi: 10.1016/j.cct.2010.07.012. Epub 2010 Jul 30.

Systems of support to increase colorectal cancer screening and follow-up rates (SOS): design, challenges, and baseline characteristics of trial participants

Beverly B Green  1 , C Y Wang, Kathryn Horner, Sheryl Catz, Richard T Meenan, Sally W Vernon, David Carrell, Jessica Chubak, Cynthia Ko, Sharon Laing, Andy Bogart
Affiliations
Randomized Controlled Trial

Systems of support to increase colorectal cancer screening and follow-up rates (SOS): design, challenges, and baseline characteristics of trial participants

Beverly B Green et al. Contemp Clin Trials. 2010 Nov.

Erratum in

  • Contemp Clin Trials. 2012 Sep;33(5):1103

Abstract

Background: Screening decreases colorectal cancer (CRC) morbidity and mortality, yet remains underutilized. Screening breakdowns arise from lack of uptake and failure to follow-up after a positive screening test.

Objectives: Systems of support to increase colorectal cancer screening and follow-up (SOS) is a randomized trial designed to increase: (1) CRC screening and (2) follow-up of positive screening tests. The Chronic Care Model and the Preventive Health Model inform study design.

Methods: The setting is a large nonprofit healthcare organization. In part-1 study, patients age 50-75 due for CRC screening are randomized to one of 4 study conditions. Arm 1 receives usual care. Arm 2 receives automated support (mailed information about screening choices and fecal occult blood tests (FOBT)). Arm 3 receives automated and assisted support (a medical assistant telephone call). Arm 4 receives automated, assisted, and care management support (a registered nurse provides behavioral activation and coordination of care). In part-2, study patients with a positive FOBT or adenomas on flexible sigmoidoscopy are randomized to receive either usual care or nurse care management. Primary outcomes are: 1) the proportion with CRC screening, 2) the proportion with a complete diagnostic evaluation after a positive screening test.

Results: We sent recruitment letters to 15,414 patients and 4675 were randomized. Randomly assigned treatment groups were similar in age, sex, race, education, self-reported health, and CRC screening history.

Conclusions: We will determine the effectiveness and cost effectiveness of stepped increases in systems of support to increase CRC screening and follow-up after a positive screening test over 2years.

Trial registration: ClinicalTrials.gov NCT00697047.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Flow of SOS Trial Patients Through Recruitment, Intervention, and Blinded Follow-up Assessments (Consort Diagram)
Figure 3
Figure 3
Preventive Health Model of Adherence
See this image and copyright information in PMC

References

    1. Hewitson P, Glasziou P, Irwig L, Towler B, Watson E. Screening for colorectal cancer using the faecal occult blood test, Hemoccult. Cochrane Database Syst Rev. 2007:CD001216. - PMC - PubMed
    1. U.S. Preventive Services Task Force Screening for Colorectal Cancer: An Updated Systematic Review. Evidence Synthesis: Agency for Healthcare Research and Quality. 2008.
    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun M. Cancer statistics, 2009. CA: A Cancer Journal for Clinicians. 2009;59:225. - PubMed
    1. Centers for Disease Control and Prevention Use of colorectal cancer tests--United States, 2002, 2004, and 2006. MMWR Morb Mortal Wkly Rep. 2008;57:253–8. - PubMed
    1. Wagner EH, Austin BT, Von Korff M. Organizing care for patients with chronic illness. Milbank Q. 1996;74:511–44. - PubMed

Publication types

MeSH terms

Associated data