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Review
. 2010 Sep;24(3):809-33.
doi: 10.1016/j.idc.2010.07.001.

Antiviral drug resistance: mechanisms and clinical implications

Lynne Strasfeld  1 , Sunwen Chou
Affiliations
Review

Antiviral drug resistance: mechanisms and clinical implications

Lynne Strasfeld et al. Infect Dis Clin North Am. 2010 Sep.

Erratum in

  • Infect Dis Clin North Am. 2010 Sep;24(3):xi

Abstract

Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of mechanisms of resistance, and the development of new antivirals. This article discusses drug resistance in herpesviruses and hepatitis B.

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