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Review
. 2010 Dec 15;53(5):1170-9.
doi: 10.1016/j.jpba.2010.07.005. Epub 2010 Jul 13.

Chiral analysis of pharmaceuticals by capillary electrophoresis using antibiotics as chiral selectors

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Review

Chiral analysis of pharmaceuticals by capillary electrophoresis using antibiotics as chiral selectors

Aleksandra F Prokhorova et al. J Pharm Biomed Anal. .

Abstract

The review summarizes the use of the chiral capillary electrophoresis (CE) with different class of antibiotics as chiral selectors in the pharmaceutical field. Basic factors influencing the enantioseparation are shortly discussed. Non-aqueous capillary electrophoresis is also included as well as the coupling of CE to MS. The selection of a chiral selector according the ionic state and structure of the analyte is described. Summary of pharmaceutical applications of chiral CE is given.

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