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. 2010 May;51(5):493-6.

Feline urate urolithiasis

Sherry L Appel  1 , Doreen M Houston, Andrew E P Moore, J Scott Weese
Affiliations

Feline urate urolithiasis

Sherry L Appel et al. Can Vet J. 2010 May.

Abstract
in English, French

This retrospective case control study describes associations between feline urate urolithiasis and breed, age, gender, and urine composition. Data from cases of feline uroliths submitted to the Canadian Veterinary Urolith Centre (CVUC) between February 2, 1998 and July 7, 2007 were reviewed. There were 10 083 feline uroliths examined, including 385 ammonium urate, 13 uric acid, and 21 mixed struvite/urate uroliths. The Egyptian Mau, Birman, and Siamese breeds were significantly predisposed to urate urolithiasis [odds ratio (OR) = 118, 95% confidence interval (CI) = 38.2 to 510, P < 0.001], (OR = 9.1, 95% CI = 2.0 to 32, P < 0.001) and (OR = 3.9, 95% CI = 2.5 to 5.9, P < 0.001), respectively. Urate urolithiasis was more frequent in younger cats (mean age 6.3 versus 7.1 y in cats with other uroliths, P < 0.0001) and in male cats (P = 0.024). The association between Egyptian Maus and urate urolithiasis was remarkable. The association in Siamese cats is consistent with prior reports, and the association with Birman cats requires further study.

Urolithiase d’urate féline. Cette étude rétrospective de cas témoins décrit les associations entre l’urolithiase d’urate féline et la race, l’âge, le sexe et la composition de l’urine. Les données de cas d’urolithes félins soumis au Centre canadien vétérinaire d’urolithiase (CCVU) entre le 2 février 1998 et le 7 juillet 2007 ont été examinées. On a examiné 10 083 urolithes félins, incluant 385 d’urate d’ammonium, 13 d’acide urique et 21 d’urolithes mélangés d’urate/struvite. Les chats de races Mau égyptien, Birman et Siamois présentaient une prédisposition significative à l’urolithiase d’urate [rapport de cotes (RC) = 118, 95 % intervalle de confiance (IC) = 38,2 à 510, P < 0,001], (RC = 9,1, 95 % IC = 2,0 à 32, P < 0,001) et (RC = 3,9, 95 % IC = 2,5 à 5,9, P < 0,001), respectivement. L’urolithiase d’urate était plus fréquente chez les jeunes chats (âge moyen de 6,3 ans contre 7,1 ans chez les chats avec d’autres urolithes, P < 0,0001) et chez les chats mâles (P = 0,024). L’association entre les Maus égyptiens et les urolithiases d’urate était remarquable. L’association chez les chats Siamois était conforme à celle présentée dans des rapports antérieurs et l’association chez les chats Birmans exige de nouvelles études.

(Traduit par Isabelle Vallières)

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Figures

Figure 1
Figure 1
Purine metabolic pathway (XO — xanthine oxidase; UC — Uricase).
See this image and copyright information in PMC

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