Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul 29:16:1448-52.

Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis

David Salom  1 , Empar Sanz-Marco, Jose L Mullor, Maria Jesus Lopez-Prats, Salvador Garcia-Delpech, Patricia Udaondo, Jose Maria Millan, J Fernando Arevalo, Manuel Diaz-Llopis
Affiliations

Aqueous humor neutrophil gelatinase-associated lipocalin levels in patients with idiopathic acute anterior uveitis

David Salom et al. Mol Vis. .

Abstract

Purpose: The purpose of this study was to evaluate the levels of neutrophil gelatinase-associated lipocalin (NGAL) in the aqueous humor in eyes with idiopathic acute anterior uveitis (AAU).

Methods: A comparative control study. Aqueous humor was collected from 20 eyes of 20 patients with idiopathic AAU. The control group included 20 aqueous samples from 20 patients about to undergo cataract surgery and without any other ocular or systemic diseases. The level of NGAL was determined with a commercially available ELISA kit.

Results: The concentration of NGAL in aqueous humor was markedly higher in patients with idiopathic AAU than in control subjects (Mann-Whitney U test, p<0.001). The level of NGAL was 139,197.38+/-183,426.36 (mean+/-SD) pg/ml in eyes with AAU and 3,169.96+/-1,595.78 pg/ml in the eyes of the control group.

Conclusions: The aqueous humor NGAL level is increased in eyes with idiopathic AAU. These results imply that NGAL is associated with the regulation of inflammation in patients with AAU and could be used as a biomarker of ocular inflammation and immunomodulatory treatment response.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Levels of neutrophil gelatinase-associated lipocalin (NGAL) in aqueous humor of 20 eyes with idiopathic acute anterior uveitis (AAU) and 20 control eyes. NGAL levels were different in both groups; patients with AAU had significantly higher levels than in the control group (Mann–Whitney U test p<0.001).
See this image and copyright information in PMC

References

    1. Suttorp-Schulten MS, Rothova A. The possible impact of uveitis in blindness: a literature survey. Br J Ophthalmol. 1996;80:844–8. - PMC - PubMed
    1. Gritz DC, Wong IG. Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study. Ophthalmology. 2004;111:491–500. - PubMed
    1. Muhaya M, Calder V, Towler HM, Shaer B, McLauchlan M, Lightman S. Characterization of T cells and cytokines in the aqueous humour (AH) in patients with Fuch’s heterochromic cyclitis (FHC) and idiopathic anterior uveitis. Clin Exp Immunol. 1998;111:123–8. - PMC - PubMed
    1. Ongkosuwito JV, Feron EJ, Van Doornik CE, Van der Lelij A, Hoyng CB, La Heij EC, Kijlstra A. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Invest Ophthalmol Vis Sci. 1998;39:2659–65. - PubMed
    1. Santos Lacomba M, Marcos Martín C, Gallardo Galera JM, Gómez Vidal MA, Collantes Estévez E, Ramírez Chamond R, Omar M. Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. 2001;33:251–5. - PubMed

LinkOut - more resources