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Case Reports
. 2010;21(2):183-5.

Balanced translocation in mother leading to interchange trisomy 21?

K M Girisha  1 , M Rajasekhar, P M Gopinath, K Satyamoorthy
Affiliations
  • PMID: 20681218
Case Reports

Balanced translocation in mother leading to interchange trisomy 21?

K M Girisha et al. Genet Couns. 2010.

Abstract

We report an unusual balanced translocation involving chromosomes 4 and 21 in a lady who had Down syndrome in her previous child. The most plausible explanation for this event is the 3:1 segregation of chromosomes at meiosis in her gametes leading to interchange trisomy 21.

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