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Review
. 2010 Jul;19(3):479-92.
doi: 10.1016/j.chc.2010.03.003.

Neurobiology of adolescent substance use disorders: implications for prevention and treatment

Helena J V Rutherford  1 , Linda C Mayes, Marc N Potenza
Affiliations
Review

Neurobiology of adolescent substance use disorders: implications for prevention and treatment

Helena J V Rutherford et al. Child Adolesc Psychiatr Clin N Am. 2010 Jul.

Abstract

Adolescence represents a unique period of development with neuronal maturation accompanied by increases in behavioral risk taking. Although risky behavior is a likely marker of normative adolescent development, there is an early emergence of substance use disorders in this population. Adolescence represents a distinct period of vulnerability to substance use initiation and transitions to substance abuse and dependence. Of recent interest is understanding the neurobiology of adolescent substance use disorders, with adult studies being limited in their applicability to this developmentally sensitive maturation period and providing restricted insight into potential treatment and intervention. First, the authors review the neurobiology of adolescent substance use disorders and, second, the authors consider the implications of these findings for prevention and treatment.

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References

    1. Wagner FA, Anthony JC. From first drug use to drug dependence - developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology. 2002;26(4):479–88. - PubMed
    1. Kelley AE, Schochet T, Landry CF. Risk taking and novelty seeking in adolescence: Introduction to part I. Ann N Y Acad Sci. 2004;1021(1):27–32. - PubMed
    1. Friedman AS, Terras A, Zhu W. Early adolescent substance use/abuse as predictor to employment in adulthood: Gender differences. Journal of Child & Adolescent Substance Abuse. 2004;13(4):49–60.
    1. Jones DR, Macias C, Barreira PJ, et al. Prevalence, severity, and co-occurrence of chronic physical health problems of persons with serious mental illness. Psychiatr Serv. 2004;55(11):1250–7. - PMC - PubMed
    1. McGue M, lacono WG. The association of early adolescent problem behavior with adult psychopathology. Am J Psychiatry. 2005;162(6):1118–24. - PubMed

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