Differential DNA damage response in stem and progenitor cells
- PMID: 20682442
- DOI: 10.1016/j.stem.2010.07.006
Differential DNA damage response in stem and progenitor cells
Abstract
The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, two groups address this hypothesis by examining DNA damage responses in hematopoietic stem and progenitor cells (Milyavsky et al., 2010; Mohrin et al., 2010).
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.Cell Stem Cell. 2010 Aug 6;7(2):174-85. doi: 10.1016/j.stem.2010.06.014. Epub 2010 Jul 8. Cell Stem Cell. 2010. PMID: 20619762 Free PMC article.
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A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.Cell Stem Cell. 2010 Aug 6;7(2):186-97. doi: 10.1016/j.stem.2010.05.016. Epub 2010 Jul 8. Cell Stem Cell. 2010. PMID: 20619763
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