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Review
. 2010 Aug 15;16(16):4071-3.
doi: 10.1158/1078-0432.CCR-10-1501. Epub 2010 Aug 3.

HER2 fragmentation and breast cancer stratification

Joaquín Arribas  1 , Josep Lluís Parra-Palau, Kim Pedersen
Affiliations
Review

HER2 fragmentation and breast cancer stratification

Joaquín Arribas et al. Clin Cancer Res. .

Abstract

HER2 is a tyrosine kinase receptor whose overexpression in breast cancers correlates with poor prognosis. A subset of HER2-positive tumors also expresses a series of HER2 fragments, collectively known as p95HER2. These fragments are emerging as a valuable biomarker for this subset of patients, who have a particularly poor prognosis.

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