Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;83(2 Suppl):14-21.
doi: 10.4269/ajtmh.2010.09-0293.

Risk factors for severe Rift Valley fever infection in Kenya, 2007

Amwayi S Anyangu  1 , L Hannah Gould, Shahnaaz K Sharif, Patrick M Nguku, Jared O Omolo, David Mutonga, Carol Y Rao, Edith R Lederman, David Schnabel, Janusz T Paweska, Mark Katz, Allen Hightower, M Kariuki Njenga, Daniel R Feikin, Robert F Breiman
Affiliations

Risk factors for severe Rift Valley fever infection in Kenya, 2007

Amwayi S Anyangu et al. Am J Trop Med Hyg. 2010 Aug.

Abstract

A large Rift Valley fever (RVF) outbreak occurred in Kenya from December 2006 to March 2007. We conducted a study to define risk factors associated with infection and severe disease. A total of 861 individuals from 424 households were enrolled. Two hundred and two participants (23%) had serologic evidence of acute RVF infection. Of these, 52 (26%) had severe RVF disease characterized by hemorrhagic manifestations or death. Independent risk factors for acute RVF infection were consuming or handling products from sick animals (odds ratio [OR] = 2.53, 95% confidence interval [CI] = 1.78-3.61, population attributable risk percentage [PAR%] = 19%) and being a herds person (OR 1.77, 95% CI = 1.20-2.63, PAR% = 11%). Touching an aborted animal fetus was associated with severe RVF disease (OR = 3.83, 95% CI = 1.68-9.07, PAR% = 14%). Consuming or handling products from sick animals was associated with death (OR = 3.67, 95% CI = 1.07-12.64, PAR% = 47%). Exposures related to animal contact were associated with acute RVF infection, whereas exposures to mosquitoes were not independent risk factors.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Map of Kenya showing areas affected by Rift Valley fever infection in humans and animals, 2007. The names and locations of the three study sites for the risk factor study are identified by arrows.
See this image and copyright information in PMC

References

    1. Xu F, Liu D, Nunes MR, DA Rosa AP, Tesh RB, Xiao SY. Antigenic and genetic relationships among Rift Valley fever virus and other selected members of the genus Phlebovirus (Bunyaviridae) Am J Trop Med Hyg. 2007;76:1194–1200. - PubMed
    1. Daubney R, Hudson JR, Garnham PC. Enzootic hepatitis or Rift Valley fever: an undescribed virus disease of sheep, cattle, and man from east Africa. J Pathol Bacteriol. 1931;34:545–579.
    1. Faye O, Diallo M, Diop D, Bezeid OE, Bâ H, Niang M, Dia I, Mohamed SA, Ndiaye K, Diallo D, Ly PO, Diallo B, Nabeth P, Simon F, Lô B, Diop OM. Rift Valley fever outbreak with east-central African virus lineage in Mauritania, 2003. Emerg Infect Dis. 2007;13:1016–1024. http://www.cdc.gov/EID/content/13/7/1016.htm Available at. Accessed August 10, 2008. - PMC - PubMed
    1. Ringot D, Durand J-P, Tolou H, Boutin J-P, Davoust B. Rift Valley fever in Chad. Emerg Infect Dis. 2004;10:945–957. - PMC - PubMed
    1. Laughlin LW, Meegan JM, Strausbaugh LJ, Morens DM, Watten RH. Epidemic Rift Valley fever in Egypt: observations of the spectrum of human illness. Trans R Soc Trop Med Hyg. 1979;73:630–633. - PubMed

Publication types

Substances

LinkOut - more resources