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Comment
. 2010 Aug 4;29(15):2475-6.
doi: 10.1038/emboj.2010.162.

Nanog, Gli, and p53: a new network of stemness in development and cancer

Sebastian Brandner  1
Affiliations
Comment

Nanog, Gli, and p53: a new network of stemness in development and cancer

Sebastian Brandner. EMBO J. .
No abstract available

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
(A) Schematic diagram of the interaction of HH signalling on p53 and Nanog. Activating interactions are indicated by green arrows and inhibition is indicated by red symbols. The effect of HH or the HH agonist SAG are indicated by yellow arrows next to the molecules, whereas the effect of HH pathway inhibitors (Cyclopamine, siSMO) is symbolized with grey arrows. (B) Nanog promotes clonogenicity and proliferation of gliomas, and probably also has a function in the maintenance of stemness in the stem cell niche of the subventricular zone. (C) Nanog controls stemness in cerebellar stem cells and in medulloblastoma cancer (stem) cells. The developing cerebellum is illustrated on a time axis relevant for the mouse brain. Darker colours indicate higher proliferation, and circles symbolize postmitotic cells in panels (B, C). VZ, ventricular zone; Ep, ependymal layer; GCP, granule cell precursor; IGL, internal granule layer; NSC, neural stem cell; PC, Purkinje cells.
See this image and copyright information in PMC

Comment on

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