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. 2011 Apr;41(4):427-33.
doi: 10.1007/s10803-010-1072-1.

Relation of melatonin to sleep architecture in children with autism

Roberta M Leu  1 , Liya Beyderman, Emmanuel J Botzolakis, Kyla Surdyka, Lily Wang, Beth A Malow
Affiliations

Relation of melatonin to sleep architecture in children with autism

Roberta M Leu et al. J Autism Dev Disord. 2011 Apr.

Abstract

Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4-10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children's Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.

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Figures

Fig. 1
Fig. 1
Higher rates of urinary 6-sulfatoxymelatonin excretion were associated with increased percentages of N3 sleep
Fig. 2
Fig. 2
Higher rates of urinary 6-sulfatoxymelatonin excretion were associated with decreased percentages of N2 sleep
See this image and copyright information in PMC

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