The promise and realities of comparative effectiveness research

doi:10.1002/sim.3936

Comment

. 2010 Aug 30;29(19):1977-81; discussion 1996-7.

doi: 10.1002/sim.3936.

The promise and realities of comparative effectiveness research

Constantine Gatsonis¹

Affiliations

PMID: 20683886
PMCID: PMC3544942
DOI: 10.1002/sim.3936

Comment

The promise and realities of comparative effectiveness research

Constantine Gatsonis. Stat Med. 2010.

. 2010 Aug 30;29(19):1977-81; discussion 1996-7.

doi: 10.1002/sim.3936.

Author

Constantine Gatsonis¹

Affiliation

¹ Center for Statistical Sciences, Brown University, Box G-S121, Providence, RI 02912, USA. gatsonis@stat.brown.edu

PMID: 20683886
PMCID: PMC3544942
DOI: 10.1002/sim.3936

Abstract

Comparative Effectiveness Research (CER) has been given a broad and ambitious mandate. Will it be able to deliver the multifaceted and granular comparative information that it has been tasked with developing? After a discussion of the general conditions for the feasibility of CER, we focus our attention on one of the most challenging areas: the evaluation of diagnostic tests and biomarkers.

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Figures

**Figure 1**
Treatment mediates the effects of diagnostic testing

**Figure 2**
Simple randomized study of test outcomes

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Comment on

Comparative effectiveness research: Policy context, methods development and research infrastructure.
Tunis SR, Benner J, McClellan M. Tunis SR, et al. Stat Med. 2010 Aug 30;29(19):1963-76. doi: 10.1002/sim.3818. Stat Med. 2010. PMID: 20564311

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References

1. Gatsonis CA. Design of Evaluations of Imaging Technologies: Development of a paradigm. Academic Radiology. 2000;7:681–683. - PubMed
1. Bossuyt P, Lijmer J, Mol B. Randomised comparison of medical tests:sometimes invalid, not always efficient. Lancet. 2000;356:1844–47. - PubMed
1. Hillner B, Siegel B, Liu D, et al. Impact of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography (PET) alone on expected management of patients with cancer: Initial results from the National Oncologic PET Registry. J Clin Oncol. 2008;26:2155–2161. - PubMed
1. Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Cancer Collaborators. The impact of mammography and adjuvant therapy on U.S. breast cancer mortality (1975–2000): Collective Results from the Cancer Intervention and Surveillance Modeling Network. J Natl Cancer Inst Monographs. 2006;36:1–126.
1. Zauber A, Lansdorp-Vogelaar I, Knudsen A, Wilschut J, van Ballegooijen M, Kuntz K. Evaluating Test Strategies for Colorectal Cancer Screening: A Decision Analysis for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 2008;149:659–669. - PMC - PubMed

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U01 CA079778/CA/NCI NIH HHS/United States

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[1] Gatsonis CA. Design of Evaluations of Imaging Technologies: Development of a paradigm. Academic Radiology. 2000;7:681–683. - PubMed

[2] Gatsonis CA. Design of Evaluations of Imaging Technologies: Development of a paradigm. Academic Radiology. 2000;7:681–683. - PubMed

[3] Bossuyt P, Lijmer J, Mol B. Randomised comparison of medical tests:sometimes invalid, not always efficient. Lancet. 2000;356:1844–47. - PubMed

[4] Bossuyt P, Lijmer J, Mol B. Randomised comparison of medical tests:sometimes invalid, not always efficient. Lancet. 2000;356:1844–47. - PubMed

[5] Hillner B, Siegel B, Liu D, et al. Impact of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography (PET) alone on expected management of patients with cancer: Initial results from the National Oncologic PET Registry. J Clin Oncol. 2008;26:2155–2161. - PubMed

[6] Hillner B, Siegel B, Liu D, et al. Impact of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography (PET) alone on expected management of patients with cancer: Initial results from the National Oncologic PET Registry. J Clin Oncol. 2008;26:2155–2161. - PubMed

[7] Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Cancer Collaborators. The impact of mammography and adjuvant therapy on U.S. breast cancer mortality (1975–2000): Collective Results from the Cancer Intervention and Surveillance Modeling Network. J Natl Cancer Inst Monographs. 2006;36:1–126.

[8] Cancer Intervention and Surveillance Modeling Network (CISNET) Breast Cancer Collaborators. The impact of mammography and adjuvant therapy on U.S. breast cancer mortality (1975–2000): Collective Results from the Cancer Intervention and Surveillance Modeling Network. J Natl Cancer Inst Monographs. 2006;36:1–126.

[9] Zauber A, Lansdorp-Vogelaar I, Knudsen A, Wilschut J, van Ballegooijen M, Kuntz K. Evaluating Test Strategies for Colorectal Cancer Screening: A Decision Analysis for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 2008;149:659–669. - PMC - PubMed

[10] Zauber A, Lansdorp-Vogelaar I, Knudsen A, Wilschut J, van Ballegooijen M, Kuntz K. Evaluating Test Strategies for Colorectal Cancer Screening: A Decision Analysis for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 2008;149:659–669. - PMC - PubMed

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The promise and realities of comparative effectiveness research

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The promise and realities of comparative effectiveness research

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