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Comment
. 2010 Aug 30;29(19):1977-81; discussion 1996-7.
doi: 10.1002/sim.3936.

The promise and realities of comparative effectiveness research

Constantine Gatsonis  1
Affiliations
Comment

The promise and realities of comparative effectiveness research

Constantine Gatsonis. Stat Med. .

Abstract

Comparative Effectiveness Research (CER) has been given a broad and ambitious mandate. Will it be able to deliver the multifaceted and granular comparative information that it has been tasked with developing? After a discussion of the general conditions for the feasibility of CER, we focus our attention on one of the most challenging areas: the evaluation of diagnostic tests and biomarkers.

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Figures

Figure 1
Figure 1
Treatment mediates the effects of diagnostic testing
Figure 2
Figure 2
Simple randomized study of test outcomes
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