[Na+,K(+)-ATPase activity in polarized cells]

Abstract

The novel views on fundamental role of Na+,K(+)-ATPase in regulation of the polarized morphology of the epithelial cells, enzyme involvement in signal transduction, assembly of intermolecular signaling complexes have been reviewed. The modern state of researches are considered in detail, including: sorting specificity in polarized cells, Na+,K(+)-ATPase involvement in epithelial cell interactions, enzyme arrangement in combined structural and functional ensemble with adhesion and cytoskeleton proteins, their coordinated exp ression. The mechanisms of the Na+,K(+)-ATPase association with its molecular partners and the role of specific domains, motives and binding sites are analysed. The available data, including own researches indicate the Na+,K(+)-ATPase involvement in certain pathologies that develop with aberration of polarized epithelial phenotype, malignant growth in particular.