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Comparative Study
. 2011 May;64(5):497-506.
doi: 10.1016/j.jclinepi.2010.04.010. Epub 2010 Aug 4.

Five preference-based indexes in cataract and heart failure patients were not equally responsive to change

Robert M Kaplan  1 , Steven Tally, Ron D Hays, David Feeny, Theodore G Ganiats, Mari Palta, Dennis G Fryback
Affiliations
Comparative Study

Five preference-based indexes in cataract and heart failure patients were not equally responsive to change

Robert M Kaplan et al. J Clin Epidemiol. 2011 May.

Abstract

Objective: To compare the responsiveness to clinical change of five widely used preference-based health-related quality-of-life indexes in two longitudinal cohorts.

Study design and setting: Five generic instruments were simultaneously administered to 376 adults undergoing cataract surgery and 160 adults in heart failure management programs. Patients were assessed at baseline and reevaluated after 1 and 6 months. The measures were the Short Form (SF)-6D (based on responses scored from SF-36v2), Self-Administered Quality of Well-being Scale (QWB-SA), the EuroQol-5D developed by the EuroQol Group, the Health Utilities Indexes Mark 2 (HUI2) and Mark 3 (HUI3). Cataract patients completed the National Eye Institute Visual Functioning Questionnaire-25, and heart failure patients completed the Minnesota Living with Heart Failure Questionnaire. Responsiveness was estimated by the standardized response mean.

Results: For cataract patients, mean changes between baseline and 1-month follow-up for the generic indices ranged from 0.00 (SF-6D) to 0.052 (HUI3) and were statistically significant for all indexes except the SF-6D. For heart failure patients, only the SF-6D showed significant change from baseline to 1 month, whereas only the QWB-SA change was significant between 1 and 6 months.

Conclusions: Preference-based methods for measuring health outcomes are not equally responsive to change.

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Figures

Figure 1
Figure 1
Distributions of baseline scores on 5 indexes at baseline for cataract (top)and heart failure patients (bottom).
Figure 2
Figure 2
QWB-SA and HUI-3 Over Time in NHMS for Cataract Patients (Upper Panels) and Heart Failure (Lower Panels)
See this image and copyright information in PMC

References

    1. Hays RD, Kim S, Spritzer KL, et al. Effects of mode and order of administration on generic health-related quality of life scores. Value Health. 2009;12:1035–9. - PMC - PubMed
    1. Hays RD, Kim S, Spritzer KL, et al. Effects of Mode and Order of Administration on Generic Health-Related Quality of Life Scores. Value Health. 2009 - PMC - PubMed
    1. Ware JE, Jr, Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. Journal of Clinical Epidemiology. 1998;51:903–12. - PubMed
    1. Kosinski M, Keller SD, Hatoum HT, Kong SX, Ware JE., Jr The SF-36 Health Survey as a generic outcome measure in clinical trials of patients with osteoarthritis and rheumatoid arthritis: tests of data quality, scaling assumptions and score reliability. Medical Care. 1999;37:MS10–22. - PubMed
    1. Stewart AL, Ware JE. Measuring functioning and well-being: the medical outcomes study approach. Durham: Duke University Press; 1992.

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