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Review
. 2010 Aug;130(8):1011-6.
doi: 10.1248/yakushi.130.1011.

[Development and application of practical synthetic methods of imidazolines]

[Article in Japanese]
Kenichi Murai  1
Affiliations
Free article
Review

[Development and application of practical synthetic methods of imidazolines]

[Article in Japanese]
Kenichi Murai. Yakugaku Zasshi. 2010 Aug.
Free article

Abstract

This review describes the first method to prepare imidazolines from aldehydes and 1,2-diamines by condensation and successive oxidation using NBS in one-pot operation. The reaction proceeds under mild conditions and can be applied to various aromatic and aliphatic aldehydes and 1,2-diamines. The utility of this method is also demonstrated in the total synthesis of spongotine A and the preparation of a newly designed organocatalyst, C3-symmetric trisimidazoline 7.

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