doi: 10.1248/bpb.33.1443.
Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism
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- PMID: 20686246
- DOI: 10.1248/bpb.33.1443
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Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism
Biol Pharm Bull.
2010.
Free article
Abstract
A human intestinal bacterium, strain END-2, which enantioselectively oxidizes (+)-enterodiol (END) to (+)-enterolactone (ENL) through enterolactol is also responsible for demethylation during plant lignan metabolism. A free hydroxyl group adjacent to the methoxy group is required for demethylation. The bacterium transformed (+)- and (-)-secoisolariciresinol to (+)-ENL and (-)-END, respectively, by co-incubation with strain ARC-1, which is responsible for dehydroxylation.
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