The significance of non-T-cell pathways in graft rejection: implications for transplant tolerance

Abstract

Both innate and adaptive immune cells are actively involved in the initiation and destruction of allotransplants, and there is a true need now to look beyond T cells in the allograft response, examining various non-T-cell types in transplant models and how such cell types interact with T cells in determining the fate of an allograft. Studies in this area may lead to further improvement in transplant outcomes.

Fig 1

Cross-talk of non-T cells and T cells in alloimmune responses. Non-T cells can directly damage the graft or indirectly by modifying the T cell programs.