Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families
- PMID: 20686522
- PMCID: PMC4007810
- DOI: 10.1038/aps.2010.91
Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families
Abstract
Aim: To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs13418078, and rs4972504, in HOXD4.
Methods: Four hundred Chinese nuclear families with male offspring (1215 subjects) and 401 Chinese nuclear families with female offspring (1260 subjects) were recruited. BMD of the lumbar spine 1-4 (L1-4) and left proximal femur including total hip and femoral neck were measured by dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test (QTDT) was performed to investigate the association among the tagging SNPs, haplotypes and peak BMD.
Results: Only the CC genotype was identified in rs13418078 in the Chinese population, unlike other populations. We failed to find significant within-family association among these SNPs, haplotypes and peak BMD at any bone site in either male- or female-offspring nuclear families.
Conclusion: The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women.
Similar articles
-
Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families.Osteoporos Int. 2016 May;27(5):1805-15. doi: 10.1007/s00198-015-3457-7. Epub 2016 Jan 5. Osteoporos Int. 2016. PMID: 26733379
-
Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.Osteoporos Int. 2012 Jul;23(7):1889-97. doi: 10.1007/s00198-011-1835-3. Epub 2011 Nov 17. Osteoporos Int. 2012. PMID: 22089472
-
No association between polymorphisms of peroxisome [corrected] proliferator-activated receptor-gamma gene and peak bone mineral density variation in Chinese nuclear families.Osteoporos Int. 2010 May;21(5):873-82. doi: 10.1007/s00198-009-1028-5. Epub 2009 Jul 31. Osteoporos Int. 2010. PMID: 19644638
-
Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families.J Bone Miner Metab. 2017 Jul;35(4):437-447. doi: 10.1007/s00774-016-0774-7. Epub 2016 Sep 14. J Bone Miner Metab. 2017. PMID: 27628047
-
Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis.Osteoporos Int. 2007 Mar;18(3):295-305. doi: 10.1007/s00198-006-0239-2. Epub 2006 Nov 7. Osteoporos Int. 2007. PMID: 17089081 Review.
Cited by
-
Expanding the Clinical Spectrum of Osteogenesis Imperfecta Type V: 13 Additional Patients and Review.Front Endocrinol (Lausanne). 2019 Jun 12;10:375. doi: 10.3389/fendo.2019.00375. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31244780 Free PMC article.
-
Novel mutations in the SEC24D gene in Chinese families with autosomal recessive osteogenesis imperfecta.Osteoporos Int. 2017 Apr;28(4):1473-1480. doi: 10.1007/s00198-016-3866-2. Epub 2016 Dec 10. Osteoporos Int. 2017. PMID: 27942778
-
Associations of Serum Cathepsin K and Polymorphisms in CTSK Gene With Bone Mineral Density and Bone Metabolism Markers in Postmenopausal Chinese Women.Front Endocrinol (Lausanne). 2020 Feb 13;11:48. doi: 10.3389/fendo.2020.00048. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32117071 Free PMC article.
-
No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity--a Mendelian randomization study.Osteoporos Int. 2016 Mar;27(3):1031-1039. doi: 10.1007/s00198-015-3341-5. Epub 2015 Nov 20. Osteoporos Int. 2016. PMID: 26588908
-
Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating.Eur J Hum Genet. 2013 Jan;21(1):76-81. doi: 10.1038/ejhg.2012.81. Epub 2012 May 16. Eur J Hum Genet. 2013. PMID: 22588665 Free PMC article.
References
-
- Miller PD, Siris ES, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, et al. Prediction of fracture risk in postmenopausal white women with peripheral bone densitometry: evidence from the National Osteoporosis Risk Assessment. J Bone Miner Res. 2002;17:2222–30. - PubMed
-
- Flicker L, Hopper JL, Rodgers L, Kaymakci B, Green RM, Wark JD. Bone density determinants in elderly women: a twin study. J Bone Miner Res. 1995;10:1607–13. - PubMed
-
- Ralston SH, Galwey N, MacKay I, Albagha OM, Cardon L, Comnston JE, et al. Loci for regulation of bone mineral density in men and women identified by genome wide linkage scan: The FAMOS study. Hum Mol Genet. 2005;14:943–51. - PubMed
-
- Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, et al. Multiple genetic loci for bone mineral density and fractures. N Engl J Med. 2008;358:2355–65. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases