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. 2010 Dec;4(3-4):220-31.
doi: 10.1007/s11682-010-9101-4.

Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements

Melissa Lopez-Larson  1 , Janis L Breeze, David N Kennedy, Steven M Hodge, Lena Tang, Constance Moore, Anthony J Giuliano, Nikos Makris, Verne S Caviness, Jean A Frazier
Affiliations

Age-related changes in the corpus callosum in early-onset bipolar disorder assessed using volumetric and cross-sectional measurements

Melissa Lopez-Larson et al. Brain Imaging Behav. 2010 Dec.

Abstract

Corpus callosum (CC) area abnormalities have been reported in magnetic resonance imaging (MRI) studies of adults and youths with bipolar disorder (BPD), suggesting interhemispheric communication may be abnormal in BPD and may be present early in the course of illness and affect normal neuromaturation of this structure throughout the lifecycle. Neuroimaging scans from 44 youths with DSM-IV BPD and 22 healthy controls (HC) were analyzed using cross-sectional area measurements and a novel method of volumetric parcellation. Univariate analyses of variance were conducted on CC subregions using both volume and traditional area measurements. Youths with BPD had smaller middle and posterior callosal regions, and reduced typical age-related increases in CC size. The cross-sectional area and novel volumetric methodologies resulted in similar findings. Future longitudinal assessments of CC development would track the evolution of callosal abnormalities in youths with BPD and allow exploration of the functional significance of these findings.

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Figures

Fig. 1
Fig. 1
Mid-sagittal MRI of the corpus callosum subdivisions based on callosal subdivisions by Witelson (in blue). Key: CC1 = Rostrum, CC2 = Genu, CC3 = Anterior body, CC4 = Midbody, CC5 = Posterior body, CC6 = Isthmus, CC7 = Splenium
Fig. 2
Fig. 2
Three-dimensional MRI of the corpus callosum subdivisions. Key: 1 = Rostrum, 2 = Genu, 3 = Anterior body, 4 = Midbody, 5 = Posterior body, 6 = Isthmus, 7 = Splenium
Fig. 3
Fig. 3
Linear regression of the total corpus callosum volumes (cc) and age (years) in youths with bipolar disorder and healthy controls
Fig. 4
Fig. 4
Total corpus callosum volumes by age group (under 12 and 12 and older) in youths with bipolar disorder and healthy controls; unadjusted mean volumes (cc), ±95% confidence interval
Fig. 5
Fig. 5
Total CC5 volumes by age group (under 12 and 12 and older) in youths with bipolar disorder and healthy controls; unadjusted mean volumes (cc), ±95% confidence interval
Fig. 6
Fig. 6
Linear regression of the correlation between volume and area measurements for CC5 in youths with bipolar disorder and healthy controls
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