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. 2010 Aug;42(4):345-53.
doi: 10.1007/s10863-010-9303-x. Epub 2010 Aug 5.

Identification and characterization of uncoupling protein in heart and muscle mitochondria of canary birds

Malgorzata B Slocinska  1 , Zakaria Ali Moh Almsherqi, Francis E Sluse, Rachel Navet, Yuru Deng
Affiliations

Identification and characterization of uncoupling protein in heart and muscle mitochondria of canary birds

Malgorzata B Slocinska et al. J Bioenerg Biomembr. 2010 Aug.

Abstract

An uncoupling protein (cUCP) was identified in heart and skeletal muscle mitochondria of canary birds. cUCP was immunodetected using polyclonal antibodies raised against murine UCP2. Its molecular mass was similar to those of mammalian UCPs (32 kDa). The activity of cUCP was stimulated by palmitic acid (PA) and inhibited by GTP mainly in state 3 respiration. Additions of PA augmented state 4 respiration and lowered the ADP/O ratio. Thus, the activity of cUCP diverted energy from oxidative phosphorylation in state 3 respiration. cUCP in heart and skeletal muscles of canary birds might have implications in thermogenesis as well as protection against free radical production.

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