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. 2010 Sep 15;51(6):709-11.
doi: 10.1086/655892.

Recurrence after treatment for pulmonary multidrug-resistant tuberculosis

Mercedes C Becerra  1 , Sasha C Appleton, Molly F Franke, Katiuska Chalco, Jaime Bayona, Megan B Murray, Carole D Mitnick
Affiliations

Recurrence after treatment for pulmonary multidrug-resistant tuberculosis

Mercedes C Becerra et al. Clin Infect Dis. .

Abstract

We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness-that all 16 episodes were caused by the original tuberculosis strain-then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.

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