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Review
. 1991 Apr;7(4):132-6.
doi: 10.1016/0168-9525(91)90458-3.

The ZFY gene family in humans and mice

P Koopman  1 , A Ashworth, R Lovell-Badge
Affiliations
Review

The ZFY gene family in humans and mice

P Koopman et al. Trends Genet. 1991 Apr.

Abstract

For several years, ZFY (zinc finger gene on the Y chromosome) was considered the best candidate for the human testis-determining gene TDF. This gene and its close relatives have been intensely studied in the hope of understanding the molecular biology of sex determination, particularly in humans and mice. Now that there is overwhelming evidence that ZFY and TDF are distinct loci, we are left with a large body of data, and a question: what do these genes really do?

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