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Meta-Analysis

GPC5 rs2352028 variant and risk of lung cancer in never smokers

Maria Teresa Landi et al. Lancet Oncol. 2010 Aug.
No abstract available

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Conflict of interest statement

Conflicts of interest

Dr. Kari Stefansson and his team (Drs. Thorunn Rafnar, Patrick Sulem, Thorgeir Thorgeirsson, and Daniel Gudbjartsson) are shareholders of the deCODE Genetics company. No other authors have conflicts of interest to declare.

Figures

Figure 1
Figure 1
Association between rs2352028 and lung cancer risk overall and in adenocarcinoma only in never smokers (additive genetic model). Results from seven independent studies and overall meta-analysis including results from the new seven independent studies plus four previously reported studies are shown. EAGLE, Environment And Genetics in Lung cancer Etiology; PLCO, Prostate Lung Colon Ovary Screening Trial; CPS-II, Cancer Prevention Study II Nutrition; IARC, International Agency for Research on Cancer; UK, Institute of Cancer Research; Iceland, deCODE Genetics; Germany, HGF lung cancer study. Black squares indicate the odds ratios, with the size of the square inversely proportional to its variance. Horizontal lines represent 95% CI. The vertical line shows the value for no effect (odds ratio =1·0). The random effects model and test for heterogeneity was conducted with the R function “mima”; the forest plot was conducted using the R package “rmeta”.
See this image and copyright information in PMC

Comment on

  • Genetic variants and risk of lung cancer in never smokers: a genome-wide association study.
    Li Y, Sheu CC, Ye Y, de Andrade M, Wang L, Chang SC, Aubry MC, Aakre JA, Allen MS, Chen F, Cunningham JM, Deschamps C, Jiang R, Lin J, Marks RS, Pankratz VS, Su L, Li Y, Sun Z, Tang H, Vasmatzis G, Harris CC, Spitz MR, Jen J, Wang R, Zhang ZF, Christiani DC, Wu X, Yang P. Li Y, et al. Lancet Oncol. 2010 Apr;11(4):321-30. doi: 10.1016/S1470-2045(10)70042-5. Epub 2010 Mar 19. Lancet Oncol. 2010. PMID: 20304703 Free PMC article.

References

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