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. 1978 Mar;75(3):1314-8.
doi: 10.1073/pnas.75.3.1314.

Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells

R McGee, P Simpson, C Christian, M Mata, P Nelson, M Nirenberg

Regulation of acetylcholine release from neuroblastoma x glioma hybrid cells

R McGee et al. Proc Natl Acad Sci U S A. 1978 Mar.

Abstract

Neuroblastoma x glioma NG108-15 hybrid cells exposed to N6, O2'-dibutyryladenosine 3':5'-cyclic monophosphate for several days release [3H]acetylcholine in response to serotonin, prostaglandin F2alpha, KCl, or veratridine. NG108-15 cells grown in the absence of dibutyrul cyclic AMP do not respond to an excitatory stimulus by releasing [3H]acetylcholine but can be shifted to a responsive state by treatment with dibutyryl cyclic AMP. Thus, the reactions that are required for acetylcholine release can be regulated in NG108-15 cells, thereby regulating the ability of cells to form synapses and the efficiency of synaptic communication.

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