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. 2009 Apr 30:3:53-8.
doi: 10.4137/cmo.s1012.

Photodynamic diagnosis for superficial bladder cancer: do all risk-groups profit equally from oncological and economic long-term results?

Wolfgang Otto  1 , Maximilian Burger, Hans-Martin Fritsche, Andreas Blana, Wolfgang Roessler, Ruth Knuechel, Wolf F Wieland, Stefan Denzinger
Affiliations

Photodynamic diagnosis for superficial bladder cancer: do all risk-groups profit equally from oncological and economic long-term results?

Wolfgang Otto et al. Clin Med Oncol. .

Abstract

Objective: Photodynamic diagnosis (PDD) of superficial bladder cancer decreases recurrence rates. We present oncological results of a randomized, prospective study, comparing transurethral resection (TUR) performed under conventional white light (WL) with PDD. The follow-up period is the longest reported to date. As costs might be reimbursed by prolonged recurrence-free survival in certain patients cost analysis in regard to risk-groups was performed.

Material and methods: Using chi-square test and log-rank test we compared recurrence rates of 103 patients after WL-TUR and of 88 patients after PDD-TUR. Cost analysis was performed according to risk-groups of recurrence.

Results: Mean follow-up was 99 months. Recurrence rate was 57% in WL vs. 28% in PDD (p < 0.001). Costs incurred by subsequent TUR averaged euro 2310 per WL patient vs. euro 713 per PDD patient. Savings per patient by PDD amounted to euro 1597. PDD costs were reimbursed in low, intermediate and high risk patients, respectively.

Conclusions: PDD-TUR is significantly superior to conventional WL-TUR in terms of recurrence rate. While economic benefit is most prominent in intermediate risk patients, PDD related costs are reimbursed in all risk-groups.

Keywords: cost analysis; photodynamic; recurrence rate; superficial bladder cancer; transurethral resection; urothelial carcinoma.

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Figures

Figure 1.
Figure 1.
Analysis of recurrence rates after conventional white light (WL) transurethral resection and photodynamic diagnostics (PDD) in study patients.
Figure 2.
Figure 2.
Calculation of white light (WL) transurethral resection (TUR) and photodynamic diagnostics (PDD) related costs in low, intermediate and high risk patients.
See this image and copyright information in PMC

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References

    1. Jichlinski P, Leisinger HJ. Fluorescence Cystoscopy in the Management of Bladder Cancer: A Help for the Urologist! Urol Int. 2005;74:97–101. - PubMed
    1. Zaak D, Karl A, Knüchel R, Stepp H, Hartmann A, Reich O, et al. Diagnosis of urothelial carcinoma of the bladder using fluorescence endoscopy. BJU International. 2005;96:217–22. - PubMed
    1. Kriegmair M, Baumgartner R, Knuechel R, Steinbach P, Ehsan A, Lumper W, et al. Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid. Urology. 1994;44:836–41. - PubMed
    1. Jocham D. Photodynamic procedures in urology. Urologe (A) 1994;33:547–52. - PubMed
    1. Filbeck T, Pichlmeier U, Knuechel R, Wieland WF, Roessler W. Senkung des Rezidivrisikos oberflächlicher Harnblasenkarzinome mittels 5-Aminolävulinsäure-induzierter Fluoreszenzdiagnostik. Urologe (A) 2003;42:1366–73. - PubMed