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Case Reports
. 2009 Apr 28:3:59-62.
doi: 10.4137/cmo.s993.

Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Recurrent Anal Cancer After Chemoradiation and Negative Forceps Biopsies: A Case Report

Julia Leblanc  1 , Pradermchai Kongkam
Affiliations
Case Reports

Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) Diagnosis of Recurrent Anal Cancer After Chemoradiation and Negative Forceps Biopsies: A Case Report

Julia Leblanc et al. Clin Med Oncol. .

Abstract

A 69-year-old woman with a history of uT2 N0 post-treated anal squamous cell cancer (SCC) presented for EUS for perianal pain. Two months prior, a digital rectal examination was significant for an indurated lesion on the left lateral rectal wall just proximal to the dentate line. A sigmoidoscopy revealed mild narrowing of the anal canal and an ulcerated friable mucosa in the same area. A biopsy demonstrated ulceration without malignancy. EUS showed a hypoechoic, non-circumferential, left-sided distal rectal mass. EUS-FNA was performed. Cytology demonstrated poorly differentiated SCC. This was confirmed by subsequent surgical resection. While endoscopic biopsy of suspected anal recurrences is usually sufficient, histologic or cytologic confirmation are necessary, as radiation-induced changes are difficult to differentiate from tumor recurrence. This case demonstrates that EUS-FNA is useful in surveillance of anal SCC when there is a high clinical suspicion of recurrence.

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Figures

Figure 1.
Figure 1.
Radial EUS revealed a hypo-echoic, left-sided distal rectal mass.
Figure 2.
Figure 2.
The mass was non-circumferential with poorly defined borders and encompassed approximately 50% of the circumference of the distal rectum.
Figure 3.
Figure 3.
EUS-FNA of the tumor recurrence.
Figure 4.
Figure 4.
EUS-FNA aspirate (Hematoxylin and Eosin staining, 40 X) revealing poorly differentiated squamous cell carcinoma of the anal canal. Peripheral nuclear palisading cells are seen.
Figure 5.
Figure 5.
Surgical histology (Hematoxylin and Eosin staining, 40 X) revealing poorly differentiated squamous cell carcinoma.
See this image and copyright information in PMC

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