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Case Reports
. 2010 Feb 24;2(1):5-11.
doi: 10.1159/000286280.

Cerebrospinal Fluid Biomarkers in Diagnosing Alzheimer's Disease in Clinical Practice: An Illustration with 3 Case Reports

Diane Slats  1 , Petra E Spies, Magnus J C Sjögren, Frans R J Verhey, Marcel M Verbeek, Marcel G M Olde Rikkert
Affiliations
Case Reports

Cerebrospinal Fluid Biomarkers in Diagnosing Alzheimer's Disease in Clinical Practice: An Illustration with 3 Case Reports

Diane Slats et al. Case Rep Neurol. .

Abstract

Analysis of the brain specific biomarkers amyloid beta(42) (Abeta(42)) and total tau (t-tau) protein in cerebrospinal fluid (CSF) has a sensitivity and specificity of more than 85% for differentiating Alzheimer's Disease (AD) from non-demented controls. International guidelines are contradictory in their advice on the use of CSF biomarkers in AD diagnostics, resulting in a lack of consistency in clinical practice. We present three case reports that illustrate clinical practice according to the Dutch and European guidelines and portray the value of CSF biomarker analysis as an add-on diagnostic to the standard diagnostic workup for AD.

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Figures

Fig. 1
Fig. 1
MRI of case 2. Transversal T2-FLAIR showing frontal cortical and asymmetrical left temporal lobe atrophy.
See this image and copyright information in PMC

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