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. 2009 Dec;13(4):25-36.

Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes

C Kilewo  1 , U C M Natchu, A Young, D Donnell, E Brown, J S Read, U Sharma, B H Chi, R Goldenberg, I Hoffman, T E Taha, W W Fawzi
Affiliations

Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes

C Kilewo et al. Afr J Reprod Health. 2009 Dec.

Abstract

This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.

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