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Review
. 2010 Dec;12(14-15):1091-101.
doi: 10.1016/j.micinf.2010.07.014. Epub 2010 Aug 5.

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence

Christina L Stallings  1 , Michael S Glickman
Affiliations
Review

Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence

Christina L Stallings et al. Microbes Infect. 2010 Dec.

Abstract

Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.

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