Comment
doi: 10.1016/j.cell.2010.07.032.
Fyn-tau-amyloid: a toxic triad
Affiliations
- PMID: 20691893
- DOI: 10.1016/j.cell.2010.07.032
Item in Clipboard
Comment
Fyn-tau-amyloid: a toxic triad
Cell.
.
Free article
Abstract
The axonal protein tau and amyloid beta-peptide (Abeta) are key players in the pathogenesis of Alzheimer's disease, and tau mediates Abeta toxicity, but it is not clear how. Ittner et al. (2010) now report an unexpected physiological function for tau in neuronal dendrites that may explain how tau mediates Abeta toxicity.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.Cell. 2010 Aug 6;142(3):387-97. doi: 10.1016/j.cell.2010.06.036. Epub 2010 Jul 22. Cell. 2010. PMID: 20655099
Similar articles
-
Dissecting toxicity of tau and beta-amyloid.Neurodegener Dis. 2010;7(1-3):10-2. doi: 10.1159/000283475. Epub 2010 Feb 13. Neurodegener Dis. 2010. PMID: 20160450
-
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.Neurobiol Aging. 2009 Sep;30(9):1379-92. doi: 10.1016/j.neurobiolaging.2007.11.017. Epub 2008 Jan 10. Neurobiol Aging. 2009. PMID: 18187234
-
Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.Brain. 2009 May;132(Pt 5):1335-45. doi: 10.1093/brain/awp023. Epub 2009 Feb 27. Brain. 2009. PMID: 19251756
-
Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?J Neurochem. 2006 Aug;98(4):993-1006. doi: 10.1111/j.1471-4159.2006.03955.x. Epub 2006 Jun 19. J Neurochem. 2006. PMID: 16787410 Review.
-
[Abeta, tau and alpha-synuclein and glial cells].Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Feb;26(1):23-31. Nihon Shinkei Seishin Yakurigaku Zasshi. 2006. PMID: 16637593 Review. Japanese.
Cited by
-
Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes.Sci Rep. 2017 Mar 7;7:43651. doi: 10.1038/srep43651. Sci Rep. 2017. PMID: 28266558 Free PMC article.
-
Post-status epilepticus treatment with the Fyn inhibitor, saracatinib, improves cognitive function in mice.BMC Neurosci. 2021 Jan 15;22(1):2. doi: 10.1186/s12868-020-00606-z. BMC Neurosci. 2021. PMID: 33451301 Free PMC article.
-
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.J Neurosci. 2011 Jan 12;31(2):700-11. doi: 10.1523/JNEUROSCI.4152-10.2011. J Neurosci. 2011. PMID: 21228179 Free PMC article.
-
TNF-α Levels Are Increased in Patients with Subjective Cognitive Impairment and Are Negatively Correlated with β Amyloid-42.Antioxidants (Basel). 2024 Feb 8;13(2):216. doi: 10.3390/antiox13020216. Antioxidants (Basel). 2024. PMID: 38397814 Free PMC article.
-
Development of a new DNA vaccine for Alzheimer disease targeting a wide range of aβ species and amyloidogenic peptides.PLoS One. 2013 Sep 27;8(9):e75203. doi: 10.1371/journal.pone.0075203. eCollection 2013. PLoS One. 2013. PMID: 24086465 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous
