Noncoding RNAs: the missing "linc" in p53-mediated repression
- PMID: 20691894
- DOI: 10.1016/j.cell.2010.07.029
Noncoding RNAs: the missing "linc" in p53-mediated repression
Abstract
The tumor suppressor protein p53 coordinates the cellular response to stress through regulation of gene expression. Now, Huarte et al. (2010) identify a long intergenic noncoding RNA as a new player in p53-mediated repression of genes involved in apoptosis.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.Cell. 2010 Aug 6;142(3):409-19. doi: 10.1016/j.cell.2010.06.040. Cell. 2010. PMID: 20673990 Free PMC article.
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