Stem cells and DNA damage: persist or perish?
- PMID: 20691895
- DOI: 10.1016/j.cell.2010.07.030
Stem cells and DNA damage: persist or perish?
Abstract
Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis.Cell Stem Cell. 2010 Aug 6;7(2):174-85. doi: 10.1016/j.stem.2010.06.014. Epub 2010 Jul 8. Cell Stem Cell. 2010. PMID: 20619762 Free PMC article.
-
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.Cell Stem Cell. 2010 Aug 6;7(2):186-97. doi: 10.1016/j.stem.2010.05.016. Epub 2010 Jul 8. Cell Stem Cell. 2010. PMID: 20619763
Similar articles
-
Differential DNA damage response in stem and progenitor cells.Cell Stem Cell. 2010 Aug 6;7(2):145-7. doi: 10.1016/j.stem.2010.07.006. Cell Stem Cell. 2010. PMID: 20682442
-
Differentiation potential of germ line stem cells derived from the postnatal mouse ovary.Differentiation. 2010 Mar;79(3):159-70. doi: 10.1016/j.diff.2010.01.001. Epub 2010 Feb 6. Differentiation. 2010. PMID: 20138422
-
Gene therapy progress and prospects: stem cell plasticity.Gene Ther. 2005 Aug;12(16):1229-34. doi: 10.1038/sj.gt.3302571. Gene Ther. 2005. PMID: 15973440 Review.
-
Physician Education: Myelodysplastic Syndrome.Oncologist. 1996;1(4):284-287. Oncologist. 1996. PMID: 10388004
-
Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R210-9. doi: 10.1093/hmg/ddl175. Hum Mol Genet. 2006. PMID: 16987886 Review.
Cited by
-
Long-term quiescent fibroblast cells transit into senescence.PLoS One. 2014 Dec 22;9(12):e115597. doi: 10.1371/journal.pone.0115597. eCollection 2014. PLoS One. 2014. PMID: 25531649 Free PMC article.
-
A sensitive and quantitative polymerase chain reaction-based cell free in vitro non-homologous end joining assay for hematopoietic stem cells.PLoS One. 2012;7(3):e33499. doi: 10.1371/journal.pone.0033499. Epub 2012 Mar 20. PLoS One. 2012. PMID: 22448248 Free PMC article.
-
DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3931-6. doi: 10.1073/pnas.1213394110. Epub 2013 Feb 15. Proc Natl Acad Sci U S A. 2013. PMID: 23417300 Free PMC article.
-
Phosphorylation-mediated disassembly of C-terminal binding protein 2 tetramer impedes epigenetic silencing of pluripotency in mouse embryonic stem cells.Nucleic Acids Res. 2024 Dec 11;52(22):13706-13722. doi: 10.1093/nar/gkae1076. Nucleic Acids Res. 2024. PMID: 39588763 Free PMC article.
-
Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury.Sci Rep. 2016 Nov 23;6:37667. doi: 10.1038/srep37667. Sci Rep. 2016. PMID: 27876863 Free PMC article.
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources