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Review
. 2010 Dec;39(8):667-71.
doi: 10.1016/j.jgyn.2010.06.002. Epub 2010 Aug 6.

[Fetal hepatosplenomegaly in the third trimester: A sign of leukemia in fetuses with Down syndrome]

[Article in French]
C Fouché  1 , A Ramos, O Esperandieu, S Briault, J-G Martin, A Desroches
Affiliations
Free article
Review

[Fetal hepatosplenomegaly in the third trimester: A sign of leukemia in fetuses with Down syndrome]

[Article in French]
C Fouché et al. J Gynecol Obstet Biol Reprod (Paris). 2010 Dec.
Free article

Abstract

Risk for leukemic conditions increases in individuals with Down syndrome. We report a third trimester antenatal diagnosis of leukemia in a Down syndrome fetus. The third trimester ultrasound examination revealed a hepatosplenomegaly, which may suggest a myelopoiesis disorder. A review of the literature of eight cases described antenatally and 14 cases in the immediate neonatal period is presented.

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